Sorry but it's not possible to give you an anwser because:There's no such thing as central University of Madrid Campus . There are several universities (public and private) and several campuses in different places, so we can't guess which one you mean. Then we don't know what day of the week or time you're coming. If it's rush hour, on a bad day a short trip may take forever. There are several RENFE (not RENFRA) stations in Madrid. The one where AVE leaves from is called Estacif3n de Atocha. The best thing you can do when you arrive is skipping a taxi at all, it will cost you a fortune and if it's rusht hour you'll take forever from the airport to the station. You could take the underground from the Airport to Nuevos Ministerios (some 15 minutes) and there take the RENFE Cercanedas (commuter trains) from there to Atocha, (around 12-15 minutes) and you'll only have to walk from the commuter platforms to the long distance platforms. Like 3 minutes.That assuming you don't have a lot of luggage.To be on the safe side, I'd give at least 3 hours between flight arrivalt time and train departure time. And this means no visits to any campuses, as none of them are on the way from the Airport to the station.But if your flight is delayed (and you can never know if it will) there's no safe side , really. And arriving 6 hours earlier and having to wait is no fun.My suggestion is, if you're coming from abroad, it wouldn't cost so much to have a ticket directly to Seville, so you would avoid all the nuisance of picking up your luggages, going to the other end of Madrid with your luggage and taking a train there. Maybe it's not too late to do that